Channelpedia

PubMed 8953041


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.5



Title: Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain.

Authors: T C Holmes, D A Fadool, R Ren, I B Levitan

Journal, date & volume: Science, 1996 Dec 20 , 274, 2089-91

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/8953041


Abstract
The human Kv1.5 potassium channel (hKv1.5) contains proline-rich sequences identical to those that bind to Src homology 3 (SH3) domains. Direct association of the Src tyrosine kinase with cloned hKv1.5 and native hKv1.5 in human myocardium was observed. This interaction was mediated by the proline-rich motif of hKv1.5 and the SH3 domain of Src. Furthermore, hKv1.5 was tyrosine phosphorylated, and the channel current was suppressed, in cells coexpressing v-Src. These results provide direct biochemical evidence for a signaling complex composed of a potassium channel and a protein tyrosine kinase.