Referenced in: none

Automatically associated channels: Kv11.1 , Slo1

Title: Ion channels: structure of a molecular brake.

Authors: M S Sansom

Journal, date & volume: Curr. Biol., 1999 Mar 11 , 9, R173-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10074448

Abstract
A combination of crystallographic and mutagenesis studies on the HERG K+ channel, a key determinant of cardiac excitability, has suggested how the protein's extramembraneous amino-terminal domain might act as a 'molecular brake' that slows down channel deactivation.