Referenced in: none

Automatically associated channels: Kv1.1

Title: Abnormal distributions of potassium channels in human neuromas.

Authors: J D England, L T Happel, Z P Liu, C L Thouron, D G Kline

Journal, date & volume: Neurosci. Lett., 1998 Oct 9 , 255, 37-40

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9839721

Abstract
Twenty-seven human traumatic neuromas were examined immunocytochemically using highly specific antibodies directed against the voltage-gated delayed-rectifier potassium channel, Kv1.1. Normal sural nerves from six of the above-noted patients served as control specimens. Additionally, nine of the neuromas and two of the sural nerves were immunostained for voltage-gated calcium channels using an antibody that reacts with a wide spectrum of calcium channels. Normal myelinated fibers showed Kv1.1 specific immunoreactivity only at the juxtaparanodal regions. In contrast, within the neuromas approximately 30% of the myelinated fibers exhibited Kv1.1 specific immunoreactivity in dense patches along internodal axonal regions. The clustering of Kv1.1 channels along myelin-ensheathed internodal segments of axon was highly specific for the neuromas, and was never seen in normal nerve. Specific calcium channel immunoreactivity was not detectable in either the neuromas or sural nerves. Taken together with prior studies on sodium channels, these results suggest that selective and specific mechanisms control the distribution of ion channels within neuromas. Further investigation of ion channel changes within neuromas should provide a better understanding of the abnormal axonal hyperexcitability that frequently develops after nerve injury.