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PubMed 10648811


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav3.1



Title: Molecular cloning and functional expression of Ca(v)3.1c, a T-type calcium channel from human brain.

Authors: L L Cribbs, J C Gomora, A N Daud, J H Lee, E Perez-Reyes

Journal, date & volume: FEBS Lett., 2000 Jan 21 , 466, 54-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10648811


Abstract
Low voltage-activated T-type calcium channels are encoded by a family of at least three genes, with additional diversity created by alternative splicing. This study describes the cloning of the human brain alpha1G, which is a novel isoform, Ca(v)3.1c. Comparison of this sequence to genomic sequences deposited in the GenBank allowed us to identify the intron/exon boundaries of the human CACNA1G gene. A full-length cDNA was constructed, then used to generate a stably-transfected mammalian cell line. The resulting currents were analyzed for their voltage- and time-dependent properties. These properties identify this gene as encoding a T-type Ca(2+) channel.