Channelpedia

PubMed 9878260


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kir1.1 , Kir7.1



Title: Partial gene structure and assignment to chromosome 2q37 of the human inwardly rectifying K+ channel (Kir7.1) gene (KCNJ13).

Authors: C Derst, F Döring, R Preisig-Müller, J Daut, A Karschin, N Jeck, S Weber, H Engel, K H Grzeschik

Journal, date & volume: Genomics, 1998 Dec 15 , 54, 560-3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/9878260


Abstract
The novel weakly inward rectifying potassium channel Kir7.1 is a low-conductance channel that is predominantly expressed in epithelial cells. Here we describe a partial genomic characterization and the chromosomal assignment of the human Kir7.1 gene (KCNJ13). Analysis of the genomic structure using a PCR-based approach revealed a single 2088-bp intron in the coding region of KCNJ13. PCR analysis of monochromosomal and radiation hybrid panels assigns KCNJ13 to band 2q37 between markers D2S331 and D2S345. In addition, a single nucleotide polymorphism (C524-->T), leading to an exchange of a Thr with an Ile residue at amino acid position 175, was found.