PubMed 10407195

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: cacnb4

Title: Glutamate decarboxylase isoforms in thalamic nuclei in lethargic mouse model of absence seizures.

Authors: F H Lin, S Lin, Y Wang, D A Hosford

Journal, date & volume: Brain Res. Mol. Brain Res., 1999 Jul 23 , 71, 127-30

PubMed link:

To test the hypothesis that altered GABA synthesis within nucleus reticularis thalami (NRT) neurons regulates absence seizures, we analyzed and quantitated the distribution of GAD(67) and GAD(65), the rate-limiting enzymes of GABA synthesis, in thalamic nuclei from the Cacnb4lh model of absence seizures and non-epileptic (+/+) controls. In situ hybridization and Western blot results indicate a significant increase in GAD(67) expression (mRNA and protein) per cell but no change in GAD(65) in Cacnb4lh mice. These data suggest that GABA-synthesis is maintained or increased in NRT neurons in the Cacnb4lh mouse model.