PubMed 19398199

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.5

Title: Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel.

Authors: Michael F Gross, Neil A Castle, Anruo Zou, Alan D Wickenden, Weifeng Yu, Kerry L Spear

Journal, date & volume: Bioorg. Med. Chem. Lett., 2009 Jun 1 , 19, 3063-6

PubMed link:

Aryl sulfonamido tetralins based on lead compound 2a were synthesized and evaluated for Kv1.5 inhibitory activity. Several compounds having IC(50) values less then 0.1 microM were identified. Kv1.5 inhibitors have the potential to be atrium-selective agents for the treatment of atrial fibrillation.