Referenced in: none

Automatically associated channels: Kv2.1

Title: A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1.

Authors: B Bánfi, A Maturana, S Jaconi, S Arnaudeau, T Laforge, B Sinha, E Ligeti, N Demaurex, K H Krause

Journal, date & volume: Science, 2000 Jan 7 , 287, 138-42

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10615049

Abstract
Voltage-gated proton (H+) channels are found in many human and animal tissues and play an important role in cellular defense against acidic stress. However, a molecular identification of these unique ion conductances has so far not been achieved. A 191-amino acid protein is described that, upon heterologous expression, has properties indistinguishable from those of native H+ channels. This protein is generated through alternative splicing of messenger RNA derived from the gene NOH-1 (NADPH oxidase homolog 1, where NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate).