Channelpedia

PubMed 10454147


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav3.3



Title: Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit.

Authors: S Mittman, J Guo, M C Emerick, W S Agnew

Journal, date & volume: Neurosci. Lett., 1999 Jul 16 , 269, 121-4

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10454147


Abstract
The structure of CACNA1I, the gene encoding alpha1I, a human brain T Ca2+ channel alpha1 subunit, was determined by comparison of polymerase chain reaction-amplified brain cDNA and genomic sequences. The gene consists of at least 36 exons spanning at least 115,168 basepairs of chromosome 22q12.3-13.2. The predicted protein has 2016 amino acids and 28 potential phosphorylation sites. Alternative splicing of the gene occurs at two sites: cassette exon 9 and an alternative acceptor in exon 33. Molecular diversity generated by alternative splicing and post-translational modification of this and other members of the T alpha1 subunit gene family may account for the observed heterogeneity of T currents in central neurons.