Channelpedia

PubMed 10589995


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.1 , Kv1.4



Title: Exploring the architecture of potassium channels using chimaeras to reveal signal transduction.

Authors: B Chanda, J K Tiwari, A Varshney, M K Mathew

Journal, date & volume: Biosci. Rep., 1999 Aug , 19, 301-6

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/10589995


Abstract
The chimeric channel, 4N/1, generated from two outwardly rectifying K+ channels by linking the N-terminal cytoplasmic domain of hKv1.4 with the transmembrane body of hKv1.1, functions as an inward rectifier. The operating range of the channel is shifted to hyperpolarizing potentials and it is inactivated at resting membrane potentials. Co-expression of a truncated form of hKv1.1 with the N-terminal domain of hKv1.4 results in the same physiology as the chimaera implying specific interactions between the two segments.