Referenced in: none

Automatically associated channels: SK2 , SK3 , Slo1

Title: SK4 encodes intermediate conductance Ca2+-activated K+ channels in mouse urinary bladder smooth muscle cells.

Authors: S Ohya, S Kimura, M Kitsukawa, K Muraki, M Watanabe, Y Imaizumi

Journal, date & volume: Jpn. J. Pharmacol., 2000 Sep , 84, 97-100

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11043463

Abstract
The single channel current of intermediate conductance Ca2 +-activated K+ channel (IK channel) was measured in mouse urinary bladder myocytes (MBM), and the molecular basis of the channel was suggested to be the SK4 subtype by RT-PCR. Among Ca2+-activated K+ channel subtypes (SK2, SK3, SK4 and BK), the mRNAs of SK4 and BK were predominantly expressed in MBM. IK channel currents recorded from MBM showed: 38.7 pS slope conductance under symmetrical 140 mM K+ conditions, Ca2+-dependent activation, and blockade by charybdotoxin and econazole. These results strongly suggest that SK4 encodes IK channels in MBM.