PubMed 10887690

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.4 , Kv1.5 , Kv3.1 , Kv4.2

Title: [The expression of arrhythmic related genes on Xenopus oocytes for evaluation of class III antiarrhythmic drugs from ocean active material]

Authors: D H Xu, S B Xu

Journal, date & volume: Yi Chuan Xue Bao, 2000 , 27, 195-201

PubMed link:

By techniques of gene clone, microinjection and patch-clamp, human arrhythmic related gene Kv1.5 and Kv4.2 are translated mRNA, and injected into Xenopus Oocytes, respectively. A pure and single K+ current of ultrarapid delayed rectifier K+ current (Ikur) or transient outward K+ current (Ito) is respectively expressed on Xenopus Oocytes. This is a modern pharmacological model for evaluation class III antiarrhythmic drugs, overcomes many defects such as lacking human fresh cardiac muscle cells as material and co-expression of many currents on cell membrane. A new compound A1998 from Ocean material is evaluated in this model for class III antiarrhythmic functions.