Referenced in: none

Automatically associated channels: Kv11.1

Title: Regulation of the cardiac repolarizing HERG potassium channel by protein kinase A.

Authors: J Kiehn

Journal, date & volume: Trends Cardiovasc. Med., 2000 Jul , 10, 205-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/11282296

Abstract
Protein kinase A is an enzyme that regulates many cellular processes and is activated in many pathological conditions such as stress and various types of heart failure. Recently it has been shown that protein kinase A couples functionally to the HERG cardiac potassium channel, thereby altering repolarization in the heart. This link between a repolarizing potassium channel and the protein kinase system of cardiac cells may contribute to arrhythmogenesis and may become a target for future approaches to antiarrhythmic therapy.