Referenced in: none

Automatically associated channels: ClC1 , ClC4 , ClC5

Title: [Role and function of voltage-gated chloride channels of the CIC family and their defects leading to genetic diseases]

Authors: Krzysztof Dołowy, Piotr Bednarczyk, Renata Hordejuk, Beata Dworakowska, Ewa Nurowska, Wanda Jarzabek

Journal, date & volume: , 2002 , 56, 307-13

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/12194243

Abstract
There are 9 channels of the ClC family in mammals and few others in fishes, plants, yeast and bacteria. The ClC channels are present in different tissues and play a role in transmembrane potential stabilization, transepithelial transport, cell volume regulation, acidification of intracellular organelles. The genetic defects of ClC-1 chloride channel lead to myotonias, the defect in ClC-5 channel to the formation of stones in kidney, while the defect in ClC-Kb channel leads to the Bartter's syndrome.