Channelpedia

PubMed 12395102


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNQ2 , KCNQ3 , Kv7.2 , Kv7.3



Title: The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions.

Authors: I-Ching Chou, Fuu-Jen Tsai, Chao-Ching Huang, Cheng-Chieh Lin, Chang-Hai Tsai

Journal, date & volume: Neuroreport, 2002 Oct 28 , 13, 1971-3

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/12395102


Abstract
Mutations in the voltage-gated potassium channel genes KCNQ2 and KCNQ3 have been found to cause benign familial neonatal convulsions. Recent studies provided evidence that KCNQ2 and KCNQ3 contribute to the M-current, which regulates the subthreshold electrical excitability in the CNS. Febrile convulsions represent the majority of childhood seizures, and show a strong family history, suggesting a genetic predisposition. By performing an association study, we investigated whether KCNQ2 gene polymorphisms can be used as markers of susceptibility to febrile convulsions. These data suggest that the KCNQ2 gene might not be a useful marker for prediction of the susceptibility of febrile convulsions.