Referenced in: none

Automatically associated channels: Kv11.1

Title: Drugs, hERG and sudden death.

Authors: A M Brown

Journal, date & volume: Cell Calcium, 2004 Jun , 35, 543-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/15110144

Abstract
Early recognition of potential QT/TdP liability is now an essential component of the drug discovery/drug development program. The hERG assay is an indispensable step and a high-quality assay must accompany any investigational new drug (IND) application. While it is the gold standard at present, the hERG assay is too labor-intensive and too low throughput to be used as a screen early in the discovery/development process. A variety of indirect high throughput screens have been used.