Channelpedia

PubMed 12914768


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.4 , Kv1.5 , Kv3.1 , Kv4.2



Title: Thyroid hormone regulates mRNA expression and currents of ion channels in rat atrium.

Authors: Hiroshi Watanabe, Meilei Ma, Takashi Washizuka, Satoru Komura, Tsuyoshi Yoshida, Yukio Hosaka, Katsuharu Hatada, Masaomi Chinushi, Tadashi Yamamoto, Kenichi Watanabe, Yoshifusa Aizawa

Journal, date & volume: Biochem. Biophys. Res. Commun., 2003 Aug 29 , 308, 439-44

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/12914768


Abstract
Atrial fibrillation is one of the common arrhythmias associated with hyperthyroidism. This study examined the effects of thyroid hormone (T3) on mRNA expression and currents of major ionic channels determining the action potential duration (APD) in the rat atrium using the RNase protection assay and the whole-cell patch-clamp technique, respectively. T3 increased the Kv1.5 mRNA expression and decreased the L-type calcium channel mRNA expression, while the Kv4.2 mRNA expression did not change. APD was shorter in hyperthyroid than in euthyroid myocytes. The ultrarapid delayed rectifier potassium currents were remarkably increased in hyperthyroid than in euthyroid myocytes, whereas the transient outward potassium currents were unchanged. L-type calcium currents were decreased in hyperthyroid than in euthyroid myocytes. T3 shifted the current-voltage relationship for calcium currents negatively. In conclusion, T3 increased the outward currents and decreased the inward currents. The resultant changes of ionic currents shortened APD, providing a substrate for atrial fibrillation.