Channelpedia

PubMed 25433078


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: ClvC4



Title: In the beginning: a personal reminiscence on the origin and legacy of ClC-0, the 'Torpedo Cl(-) channel'.

Authors: Christopher Miller

Journal, date & volume: J. Physiol. (Lond.), 2015 Sep 15 , 593, 4085-90

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25433078


Abstract
This unapologetically subjective essay recalls the Torpedo Cl(-) channel in the years when it had neither a molecular identity nor proper name (ClC-0), and membership in a large superfamily. I discuss the circumstances surrounding its discovery and subsequent research through the 1980s that revealed its unusual molecular architecture and other strange mechanistic characteristics.