Referenced in: none

Automatically associated channels: Kv10.1

Title: Does dopamine connect the dots in ADPKD?

Authors: Arlene B Chapman

Journal, date & volume: Kidney Int., 2015 Feb , 87, 279-80

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25635722

Abstract
Healthy autosomal dominant polycystic kidney disease (ADPKD) patients with normal kidney function demonstrate reduced endothelial-dependent vasodilation that improves with increasing local dopamine levels. Dopamine regulates renal sodium excretion, and dopamine receptors are located on primary cilia in both vascular and renal tubular epithelial cells. The study by Lorthioir and colleagues links endothelial function and dopamine availability in ADPKD patients.