Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM6

Title: Expression of magnesium transporter genes in head and neck cancer patients underwent neoadjuvant cisplatin-based chemotherapy.

Authors: Yu-Jung Lin, Fu-Chou Cheng, Li-Sheng Chien, Jin-Ching Lin, Rong-San Jiang, Shih-An Liu

Journal, date & volume: Eur Arch Otorhinolaryngol, 2015 Oct , 272, 3051-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25726166

Abstract
We aimed to investigate expression of magnesium transporter genes in patients with head and neck cancer who underwent cisplatin-based neoadjuvant chemotherapy and their association with serum magnesium level. Head and neck cancer patients scheduled to undergo neoadjuvant cisplatin-based chemotherapy were eligible for enrollment. Blood samples were obtained at three time points: prior to, during, and after completion of chemotherapy. Expression levels of magnesium transporter genes were determined by quantitative real-time PCR. A total of 23 patients were included in the final analysis. The average serum magnesium levels dropped 6.98 and 5.20% during and after completion of chemotherapy. There were neither significant associations between serum magnesium level and demographic variables nor tumor-related variables. SLC41A1 expression level was positively correlated with serum magnesium whereas TRPM6 expression level was negatively correlated with serum magnesium. Serum magnesium level decreased during cisplatin-based chemotherapy in head and neck cancer patients. Further studies are warranted to investigate optimal magnesium measurement and substitution protocol.