Referenced in: none

Automatically associated channels: TRP , TRPA , TRPA1

Title: Palladium-catalyzed aerobic oxidative dehydrogenation of cyclohexenes to substituted arene derivatives.

Authors: Andrei V Iosub, Shannon S Stahl

Journal, date & volume: J. Am. Chem. Soc., 2015 Mar 18 , 137, 3454-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25734414

Abstract
A palladium(II) catalyst system has been identified for aerobic dehydrogenation of substituted cyclohexenes to the corresponding arene derivatives. Use of sodium anthraquinone-2-sulfonate (AMS) as a cocatalyst enhances the product yields. A wide range of functional groups are tolerated in the reactions, and the scope and limitations of the method are described. The catalytic dehydrogenation of cyclohexenes is showcased in an efficient route to a phthalimide-based TRPA1 activity modulator.