Referenced in: none

Automatically associated channels: Kir2.3 , TASK1

Title: Effect of metabotropic glutamate receptor-3 variants on prefrontal brain activity in schizophrenia: An imaging genetics study using multi-channel near-infrared spectroscopy.

Authors: Akihide Kinoshita, Ryu Takizawa, Shinsuke Koike, Yoshihiro Satomura, Shingo Kawasaki, Yuki Kawakubo, Kohei Marumo, Mamoru Tochigi, Tsukasa Sasaki, Yukika Nishimura, Kiyoto Kasai

Journal, date & volume: Prog. Neuropsychopharmacol. Biol. Psychiatry, 2015 Oct 1 , 62, 14-21

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25914064

Abstract
The glutamatergic system is essential for learning and memory through its crucial role in neural development and synaptic plasticity. Genes associated with the glutamatergic system, including metabotropic glutamate receptor (mGluR or GRM) genes, have been implicated in the pathophysiology of schizophrenia. Few studies, however, have investigated a relationship between polymorphism of glutamate-related genes and cortical function in vivo in patients with schizophrenia. We thus explored an association between genetic variations in GRM3 and brain activation driven by a cognitive task in the prefrontal cortex in patients with schizophrenia.Thirty-one outpatients with schizophrenia and 48 healthy controls participated in this study. We measured four candidate single nucleotide polymorphisms (rs274622, rs2299225, rs1468412, and rs6465084) of GRM3, and activity in the prefrontal and temporal cortices during a category version of a verbal fluency task, using a 52-channel near-infrared spectroscopy instrument.The rs274622 C carriers with schizophrenia were associated with significantly smaller prefrontal activation than patients with TT genotype. This between-genotype difference tended to be confined to the patient group. GRM3 polymorphisms are associated with prefrontal activation during cognitive task in schizophrenia.