PubMed 26009188

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPM , TRPML , TRPML1

Title: Regulation of TRPML1 function.

Authors: Helen Waller-Evans, Emyr Lloyd-Evans

Journal, date & volume: Biochem. Soc. Trans., 2015 Jun , 43, 442-6

PubMed link:

TRPML1 is a ubiquitously expressed cation channel found on lysosomes and late endosomes. Mutations in TRPML1 cause mucolipidosis type IV and it has been implicated in Alzheimer's disease and HIV. However, the mechanisms by which TRPML1 activity is regulated are not well understood. This review summarizes the current understanding of TRPML1 activation and regulation.