Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: Expression of Pattern Recognition Receptors by Nociceptive Metasympathetic Neurons.

Authors: L V Filippova, E Yu Bystrova, F S Malyshev, O N Platonova, A D Nozdrachev

Journal, date & volume: Bull. Exp. Biol. Med., 2015 Jun , 159, 248-52

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/26085359

Abstract
Immunohistochemical assay with double label and confocal laser scanning microscopy showed that innate immunity receptor TLR4 is expressed predominantly in neurons of the intestinal Auerbach (myenteric) plexus, while vanilloid nociceptive receptor TRPV1 is expressed by neurons of Meissner (submucous) plexus. Immunohistochemical analysis with triple labeling revealed coexpression of TLR4 and TRPV1 in enteric neurons of rat colon. The results attest to a possibility of functional interaction between Toll-like and vanilloid receptors in the neuron level.