Referenced in: none

Automatically associated channels: Kv10.1

Title: Pyroptosis: Caspase-11 Unlocks the Gates of Death.

Authors: Aude de Gassart, Fabio Martinon

Journal, date & volume: Immunity, 2015 Nov 17 , 43, 835-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/26588774

Abstract
How inflammatory caspases trigger pyroptotic cell death is mostly unexplained. In this issue of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-dependent pyroptosis.