Referenced in: none

Automatically associated channels: ClC4

Title: New perspective of ClC-Kb/2 Cl- channel physiology in the distal renal tubule.

Authors: Oleg Zaika, Viktor Tomilin, Mykola Mamenko, Vivek Bhalla, Oleh Pochynyuk

Journal, date & volume: Am. J. Physiol. Renal Physiol., 2016 May 15 , 310, F923-30

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/26792067

Abstract
Since its identification as the underlying molecular cause of Bartter's syndrome type 3, ClC-Kb (ClC-K2 in rodents, henceforth it will be referred as ClC-Kb/2) is proposed to play an important role in systemic electrolyte balance and blood pressure regulation by controlling basolateral Cl(-) exit in the distal renal tubular segments from the cortical thick ascending limb to the outer medullary collecting duct. Considerable experimental and clinical effort has been devoted to the identification and characterization of disease-causing mutations as well as control of the channel by its cofactor, barttin. However, we have only begun to unravel the role of ClC-Kb/2 in different tubular segments and to reveal the regulators of its expression and function, e.g., insulin and IGF-1. In this review we discuss recent experimental evidence in this regard and highlight unexplored questions critical to understanding ClC-Kb/2 physiology in the kidney.