PubMed 27227016

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPA , TRPA1

Title: The evolutionary divergence of TRPA1 channel: heat-sensitive, cold-sensitive and temperature-insensitive.

Authors: Jun Chen

Journal, date & volume: Temperature (Austin), 2015 Apr-Jun , 2, 158-9

PubMed link:

The Transient Receptor Potential Ankyrin 1 ion channel is heat-sensitive in invertebrate and ancestral vertebrates, cold-sensitive in rodents, and temperature-insensitive in primates. This remarkable divergence in temperature sensitivity is in contrast to its role in sensing electrophilic compounds, which is conserved during animal evolution.