Channelpedia

PubMed 27261831


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Kv1.1



Title: Atrial-Selective Potassium Channel Blockers.

Authors: Niels Voigt, Dobromir Dobrev

Journal, date & volume: Card Electrophysiol Clin, 2016 Jun , 8, 411-21

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/27261831


Abstract
Atrial fibrillation (AF) is associated with increased morbidity and mortality. Atrial-selective potassium (K(+)) channel blockers may represent a novel therapeutic target. The best validated atrial-specific ion currents are the acetylcholine-activated inward-rectifier K(+) current IK,ACh and ultrarapidly activating delayed-rectifier K(+) current IKur. Two-pore domain and small-conductance Ca(2+)-activated K(+) channels and Kv1.1 channels may also contribute to the atrial repolarization. We review the molecular and electrophysiologic characteristics of atrial-selective K(+) channels and their potential pathophysiologic role in AF. We summarize currently available K(+) channel blockers focusing on the most important compounds.