PubMed 25491304

Referenced in Channelpedia wiki pages of: none

Automatically associated channels: TRP , TRPM , TRPML , TRPML1

Title: Mucolipidosis type IV protein TRPML1-dependent lysosome formation.

Authors: Austin Miller, Jessica Schafer, Cameron Upchurch, Ellen Spooner, Julie Huynh, Sebastian Hernandez, Brooke McLaughlin, Liam Oden, Hanna Fares

Journal, date & volume: Traffic, 2015 Mar , 16, 284-97

PubMed link:

Lysosomes are dynamic organelles that undergo cycles of fusion and fission with themselves and with other organelles. Following fusion with late endosomes to form hybrid organelles, lysosomes are reformed as discrete organelles. This lysosome reformation or formation is a poorly understood process that has not been systematically analyzed and that lacks known regulators. In this study, we quantitatively define the multiple steps of lysosome formation and identify the first regulator of this process.