PubMed 25633111

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Automatically associated channels: TRP

Title: Time-resolved luminescent biosensing based on inorganic lanthanide-doped nanoprobes.

Authors: Wei Zheng, Datao Tu, Ping Huang, Shanyong Zhou, Zhuo Chen, Xueyuan Chen

Journal, date & volume: Chem. Commun. (Camb.), 2015 Mar 11 , 51, 4129-43

PubMed link:

Time-resolved (TR) photoluminescence (PL) biosensing has been widely adopted in many research and medical institutions. However, commercial molecular TRPL bioprobes like lanthanide (Ln(3+))-chelates suffer from poor photochemical stability and long-term toxicity. Inorganic Ln(3+)-doped nanocrystals (NCs), owing to their superior physicochemical properties over Ln(3+)-chelates, are regarded as a new generation of luminescent nanoprobes for TRPL biosensing. The long-lived PL of Ln(3+)-doped NCs combined with the TRPL technique is able to completely suppress the interference of the short-lived background, resulting in a background-free signal and therefore a remarkable sensitivity for biosensing. In this feature article, we summarize the latest advancements in inorganic Ln(3+)-doped NCs as TRPL nano-bioprobes from their fundamental optical properties to their potential applications for ultrasensitive biodetection and high-resolution bioimaging. Future efforts towards the commercialization of these nanoprobes are also proposed.