Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV6

Title: Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.

Authors: Taka-aki K Noguchi, Hisako Ishimine, Yoshiro Nakajima, Kanako Watanabe-Susaki, Naoki Shigeta, Norio Yamakawa, Pi-Chao Wang, Makoto Asashima, Akira Kurisaki

Journal, date & volume: Gene Expr. Patterns, 2012 Mar-Apr , 12, 154-63

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/22266179

Abstract
The mechanisms of gastrointestinal morphogenesis in mammals are not well understood. This is partly due to the lack of appropriate markers that are expressed with spatiotemporal specificity in the gastrointestinal tract during development. Using mouse embryos, we surveyed markers of the prospective stomach region during gastrointestinal morphogenesis. The initiation of organ bud formation occurs at E10.5 in mice. These primordia for the digestive organs protrude from a tube-like structured endoderm and have their own distinct morphogenesis. We identified 3 cell surface genes -Adra2a, Fzd5, and Trpv6 - that are expressed in the developing stomach region during gastrointestinal morphogenesis using a microarray-based screening. These novel genes will be useful in expanding our understanding of the mechanisms of gastrointestinal development.