Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM2

Title: Oxidative stress mediates the disruption of airway epithelial tight junctions through a TRPM2-PLCγ1-PKCα signaling pathway.

Authors: Rui Xu, Qi Li, Xiang-Dong Zhou, Juliy M Perelman, Victor P Kolosov

Journal, date & volume: Int J Mol Sci, 2013 , 14, 9475-86

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/23629676

Abstract
Oxidative stress has been implicated as an important contributing factor in the pathogenesis of several pulmonary inflammatory diseases. Previous studies have indicated a relationship between oxidative stress and the attenuation of epithelial tight junctions (TJs). In Human Bronchial Epithelial-16 cells (16HBE), we demonstrated the degradation of zonula occludens-1 (ZO-1), and claudin-2 exhibited a great dependence on the activation of the transient receptor potential melastatin (TRPM) 2 channel, phospholipase Cγ1 (PLCγ1) and the protein kinase Cα (PKCα) signaling cascade.