Referenced in: none

Automatically associated channels: Nav1.8

Title: Exon 11 skipping of SCN10A coding for voltage-gated sodium channels in dorsal root ganglia.

Authors: Jana Schirmeyer, Karol Szafranski, Enrico Leipold, Christian Mawrin, Matthias Platzer, Stefan H Heinemann

Journal, date & volume: Channels (Austin), 2014 , 8, 210-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24763188

Abstract
The voltage-gated sodium channel Na(V)1.8 (encoded by SCN10A) is predominantly expressed in dorsal root ganglia(DRG) and plays a critical role in pain perception. We analyzed SCN10A transcripts isolated from human DRGs using deep sequencing and found a novel splice variant lacking exon 11, which codes for 98 amino acids of the domain I/II linker. Quantitative PCR analysis revealed an abundance of this variant of up to 5–10% in human, while no such variants were detected in mouse or rat. Since no obvious functional differences between channels with and without the exon-11 sequence were detected, it is suggested that SCN10A exon 11 skipping in humans is a tolerated event.