Channelpedia

PubMed 25072868


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: SK4



Title: On the risk concerns of zacopride, a moderate IK1 channel agonist with cardiac protective action.

Authors: Bo-wei Wu, Ji-Min Cao

Journal, date & volume: J. Cardiovasc. Pharmacol., 2014 Oct , 64, 357-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25072868


Abstract
Zacopride, an IK1 agonist with moderate potency, could exert significant antiarrhythmic and cardiac protective effects. To date, there is no report to show that zacopride is proarrhythmic in both experimental studies and clinical trials. However, in certain cardiac pathological conditions, especially short QT syndrome and certain reentry tachycardia, zacopride is not suggested. Further studies are needed to precisely evaluate the potential arrhythmogenic risk of zacopride.