Referenced in: none

Automatically associated channels: Slo1

Title: Influence of agonist induced internalization on [3H]Ro15-4513 binding-an application to imaging fluctuations in endogenous GABA with positron emission tomography.

Authors: Darren Quelch, Vittorio De Santis, Annette Strege, James Myers, Lisa Wells, David Nutt, Anne Lingford-Hughes, Christine Parker, Robin Tyacke

Journal, date & volume: Synapse, 2015 Jan , 69, 60-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25196273

Abstract
Low affinity α1/α2 containing GABAA receptors are significantly less able to bind [(11) C]/[(3) H]Ro15-4513 following translocation to the endosomal environment. The alterations in [(11) C]Ro15-4513 binding observed in vivo following perturbations in endogenous GABA are likely driven by both alterations in receptor binding parameters following agonist induced internalisation and the GABA Shift.