Referenced in: none

Automatically associated channels: Slo1 , TRP , TRPM , TRPM7

Title: Novel insights into TRPM7 function in fibrotic diseases: a potential therapeutic target.

Authors: Tao Xu, Bao-Ming Wu, Hong-Wei Yao, Xiao-Ming Meng, Cheng Huang, Ming-Ming Ni, Jun Li

Journal, date & volume: J. Cell. Physiol., 2015 Jun , 230, 1163-9

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25204892

Abstract
"Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of physical and chemical stimuli. Activation of TRP channels changes the membrane potential, translocates important signaling ions crossing the cell membrane, alters enzymatic activity, and initiates endocytosis/exocytosis (Zheng, 2013)." Fibrosis is the leading cause of organ dysfunction in diseases, which is characterized by an imbalance in the turnover of extracellular matrix components. Accumulating evidence has demonstrated that TRPM7, a member of TRP channels superfamily, participates in the development and pathogenesis of fibrotic diseases, such as hepatic, pulmonary and cardiac fibrosis. In this review, we discuss the comprehensive role of TRPM7 in modulating profibrotic response and its potential as therapeutic target for fibrotic diseases.