Referenced in: none

Automatically associated channels: Kir2.3

Title: Supramolecular glycodendrimer-based hybrid drugs.

Authors: Marco Paolino, Hartmut Komber, Laura Mennuni, Gianfranco Caselli, Dietmar Appelhans, Brigitte Voit, Andrea Cappelli

Journal, date & volume: Biomacromolecules, 2014 Nov 10 , 15, 3985-93

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25286342

Abstract
Specific noncovalent interactions are commonly used by nature to modulate numerous processes including cell recognition, viral adhesion, and transmembrane communications. Here we report on the design, synthesis, and preliminary characterization of new supramolecular glycodendrimer-based hybrid drugs based on adamantyl-modified glycodendrimers of third, fourth, or fifth generation (mPPI-G3-AdaB, mPPI-G4-AdaB, and mPPI-G5-AdaB) and a new heterobifunctional ligand. This component was tailored to bind through noncovalent interactions both the multimeric natural 5-HT3 receptor (through an optimized arylpiperazine pharmacophore) and the adamantyl groups located on the glycodendrimer surfaces (through a β-cyclodextrin residue) giving rise to biorelevant supramolecular constructs.