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PubMed 25297323


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Title: A novel Pseudomonas aeruginosa strain with an oprD mutation in relation to a nosocomial respiratory infection outbreak in an intensive care unit.

Authors: Yingjun Yan, Xiangyu Yao, Haijing Li, Zhonghua Zhou, Wenfang Huang, Charles W Stratton, Chung-Dar Lu, Yi-Wei Tang

Journal, date & volume: J. Clin. Microbiol., 2014 Dec , 52, 4388-90

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25297323


Abstract
Seven imipenem-resistant Pseudomonas aeruginosa isolates were recovered from the sputum samples of pneumonia patients in southwestern China. They had identical antibiotic resistance patterns and indistinguishable pulsed-field gel electrophoresis profiles. Nucleotide sequence analysis revealed a 4-bp (AGTC) insertion in the oprD gene, resulting in a frameshift in the cognate open reading frame. These isolates became imipenem susceptible when the chromosomal oprD lesion was complemented, indicating that the 4-bp insertion in the oprD gene resulted in imipenem resistance.