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PubMed 25356525


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Title: Clinical and genetic investigation of 17 Japanese patients with hyperekplexia.

Authors: Jun Mine, Takeshi Taketani, Kazushi Yoshida, Fusako Yokochi, Junpei Kobayashi, Koichi Maruyama, Etsuro Nanishi, Mayumi Ono, Atsushi Yokoyama, Hidee Arai, Shiho Tamaura, Yasuhiro Suzuki, Shusuke Otsubo, Takashi Hayashi, Masahiko Kimura, Kazuko Kishi, Seiji Yamaguchi

Journal, date & volume: Dev Med Child Neurol, 2015 Apr , 57, 372-7

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25356525


Abstract
The aim of the study was to determine clinical and genetic characteristics of Japanese patients with hyperekplexia.Clinical courses, responses to antiepileptic drugs, outcomes, and genetic testing were investigated in 17 Japanese patients (nine males, eight females, median age 1y, range birth-45y) with hyperekplexia.In all patients, muscle stiffness and startle responses appeared soon after birth. Only seven patients were diagnosed with hyperekplexia before 1 year of age. Seven patients had been misdiagnosed with other disorders such as epilepsy and adult-onset anxiety neurosis. Umbilical/inguinal hernias were seen in 10 patients. Life-threatening events were noted in four patients. Clonazepam was the most effective drug. Muscle stiffness completely disappeared in 12 patients before 5 years of age, whereas startle responses resolved in only three patients. Mutations in the GLRA1 and GLRB genes were identified in 16 patients and one patient respectively. In 14 patients, the mutation showed autosomal dominant inheritance; in the other three, inheritance was autosomal recessive. p.R271Q of GLRA1 was the most frequent mutation, found in 10 patients. Novel mutations, p.A272P and p.A384P of GLRA1, were detected. Clinical severity and outcome varied even in the same family.Early correct diagnosis is essential for prevention of accidental injuries and to provide appropriate treatments for hyperekplexia. Clonazepam is effective, although the time taken for startle responses to resolve varied.