Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM4

Title: Physiological functions of the TRPM4 channels via protein interactions.

Authors: Chang-Hoon Cho, Young-Sun Lee, Eunju Kim, Eun Mi Hwang, Jae-Yong Park

Journal, date & volume: BMB Rep, 2015 Jan , 48, 1-5

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25441424

Abstract
Transient Receptor Potential, Melastatin-related, member 4 (TRPM4) channels are Ca2(+)-activated Ca2(+)-impermeable cation channels. These channels are expressed in various types of mammalian tissues including the brain and are implicated in many diverse physiological and pathophysiological conditions. In the past several years, the trafficking processes and regulatory mechanism of these channels and their interacting proteins have been uncovered. Here in this minireview, we summarize the current understanding of the trafficking mechanism of TRPM4 channels on the plasma membrane as well as heteromeric complex formation via protein interactions. We also describe physiological implications of protein-TRPM4 interactions and suggest TRPM4 channels as therapeutic targets in many related diseases.