Referenced in: none

Automatically associated channels: Kv11.1

Title: Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors.

Authors: Michael A Brodney, Elizabeth M Beck, Christopher R Butler, Gabriela Barreiro, Eric F Johnson, David Riddell, Kevin Parris, Charles E Nolan, Ying Fan, Kevin Atchison, Cathleen Gonzales, Ashley E Robshaw, Shawn D Doran, Mark W Bundesmann, Leanne Buzon, Jason Dutra, Kevin Henegar, Erik LaChapelle, Xinjun Hou, Bruce N Rogers, Jayvardhan Pandit, Ricardo Lira, Luis Martinez-Alsina, Peter Mikochik, John C Murray, Kevin Ogilvie, Loren Price, Subas M Sakya, Aijia Yu, Yong Zhang, Brian T O'Neill

Journal, date & volume: J. Med. Chem., 2015 Apr 9 , 58, 3223-52

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25781223

Abstract