PubMed 25874049

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Automatically associated channels: Kv10.1

Title: Epileptic syndromes: From clinic to genetic.

Authors: Abbas Tafakhori, Vajiheh Aghamollaii, Sara Faghihi-Kashani, Payam Sarraf, Laleh Habibi

Journal, date & volume: Iran J Neurol, 2015 Jan 5 , 14, 1-7

PubMed link:

Epilepsy is one of the most common neurological disorders. Studies have demonstrated that genetic factors have a strong role in etiology of epilepsy. Mutations in genes encoding ion channels, neurotransmitters and other proteins involved in the neuronal biology have been recognized in different types of this disease. Moreover, some chromosomal aberration including ring chromosomes will result in epilepsy. In this review, we intend to highlight the role of molecular genetic in etiology of epilepsy syndromes, inspect the most recent classification of International League against Epilepsy and discuss the role of genetic counseling and genetic testing in management of epilepsy syndromes. Furthermore, we emphasize on collaboration of neurologists and geneticists to improve diagnosis and management.