Referenced in: none

Automatically associated channels: Cav1.2 , Cav3.2 , Slo1

Title: Chronic hypoxia in pregnancy affected vascular tone of renal interlobar arteries in the offspring.

Authors: Jiaqi Tang, Zhoufeng Zhu, Shuixiu Xia, Na Li, Ningjing Chen, Qinqin Gao, Lingjun Li, Xiuwen Zhou, Dawei Li, Xiaolin Zhu, Qing Tu, Weisheng Li, Chonglong Wu, Jiayue Li, Yuan Zhong, Xiang Li, Caiping Mao, Zhice Xu

Journal, date & volume: Sci Rep, 2015 , 5, 9723

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25983078

Abstract
Hypoxia during pregnancy could affect development of fetuses as well as cardiovascular systems in the offspring. This study was the first to demonstrate the influence and related mechanisms of prenatal hypoxia (PH) on renal interlobar arteries (RIA) in the 5-month-old male rat offspring. Following chronic hypoxia during pregnancy, phenylephrine induced significantly higher pressor responses and greater vasoconstrictions in the offspring. Nitric oxide mediated vessel relaxation was altered in the RIA. Phenylephrine-stimulated free intracellular calcium was significantly higher in the RIA of the PH group. The activity and expression of L-type calcium channel (Cav1.2), not T-type calcium channel (Cav3.2), was up-regulated. The whole-cell currents of calcium channels and the currents of Cav1.2 were increased compared with the control. In addition, the whole-cell K(+) currents were decreased in the offspring exposed to prenatal hypoxia. Activity of large-conductance Ca(2+)-activated K(+) channels and the expression of MaxiKα was decreased in the PH group. The results provide new information regarding the influence of prenatal hypoxia on the development of the renal vascular system, and possible underlying cellular and ion channel mechanisms involved.