Referenced in: none

Automatically associated channels: TRP

Title: Interaction of H2S with Calcium Permeable Channels and Transporters.

Authors: Weihua Zhang, Changqing Xu, Guangdong Yang, Lingyun Wu, Rui Wang

Journal, date & volume: Oxid Med Cell Longev, 2015 , 2015, 323269

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/26078804

Abstract
A growing amount of evidence has suggested that hydrogen sulfide (H2S), as a gasotransmitter, is involved in intensive physiological and pathological processes. More and more research groups have found that H2S mediates diverse cellular biological functions related to regulating intracellular calcium concentration. These groups have demonstrated the reciprocal interaction between H2S and calcium ion channels and transporters, such as L-type calcium channels (LTCC), T-type calcium channels (TTCC), sodium/calcium exchangers (NCX), transient receptor potential (TRP) channels, β-adrenergic receptors, and N-methyl-D-aspartate receptors (NMDAR) in different cells. However, the understanding of the molecular targets and mechanisms is incomplete. Recently, some research groups demonstrated that H2S modulates the activity of calcium ion channels through protein S-sulfhydration and polysulfide reactions. In this review, we elucidate that H2S controls intracellular calcium homeostasis and the underlying mechanisms.