Referenced in: none

Automatically associated channels: Slo1

Title: 2014 Conway review lecture, Royal Academy of Medicine in Ireland: "S6, drugs and RCK and Bowl".

Authors: M A Hollywood

Journal, date & volume: Ir J Med Sci, 2015 Oct 17 , ,

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/26477033

Abstract
The Conway Review Lecture is held annually by the Royal Academy of Medicine in Ireland Biomedical Sciences Section, to remember the life and scientific work of a world class Irish scientist, Professor Edward J Conway.This years lecture will focus on large conductance Ca2+ activated K+ (BK) channels and aims to describe how a combination of techniques can be used to unravel drug effects on ion channels at a molecular level.Experiments were performed using a range of techniques including patch clamp electrophysiology, mutagenesis, structural biology and mathematical modeling.Our data suggest that the novel BK channel opener GoSlo-SR-5-6 mediates its effects via an interaction with 2 residues on S6 (S317 and I326) and a residue on the S4/S5 linker (L227).We hypothesize that this novel opener activates BK channels by altering an interaction between the S4/S5 linker and the pore-forming S6 transmembrane helix.