Referenced in: none

Automatically associated channels: TRP , TRPM , TRPM7

Title: Identification of a Mg2+-sensitive ORF in the 5'-leader of TRPM7 magnesium channel mRNA.

Authors: Inna A Nikonorova, Nikolay V Kornakov, Sergey E Dmitriev, Konstantin S Vassilenko, Alexey G Ryazanov

Journal, date & volume: Nucleic Acids Res., 2014 Nov 10 , 42, 12779-88

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25326319

Abstract
TRPM7 is an essential and ubiquitous channel-kinase regulating cellular influx of Mg2+. Although TRPM7 mRNA is highly abundant, very small amount of the protein is detected in cells, suggesting post-transcriptional regulation of trpm7 gene expression. We found that TRPM7 mRNA 5'-leader contains two evolutionarily conserved upstream open reading frames that act together to drastically inhibit translation of the TRPM7 reading frame at high magnesium levels and ensure its optimal translation at low magnesium levels, when the activity of the channel-kinase is most required. The study provides the first example of magnesium channel synthesis being controlled by Mg2+ in higher eukaryotes.