Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV1

Title: The Role of TRPV1 in Improving VSMC Function and Attenuating Hypertension.

Authors: Ming-Jie Zhang, Yan-Wei Yin, Bing-Hu Li, Yun Liu, Shao-Qiong Liao, Chang-Yue Gao, Jing-Cheng Li, Li-li Zhang

Journal, date & volume: Prog. Biophys. Mol. Biol., 2015 Mar 23 , ,

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25814480

Abstract
The transient receptor potential vanilloid type 1 (TRPV1) channel, a ligand-gated cation channel of the TRP subfamily, can be activated by multiple stimuli, including capsaicin. Currently, cumulative studies have demonstrated an interesting link between TRPV1 and cardiovascular diseases, including hypertension. Additionally, the protective effect of TRPV1 against hypertension and its related disorders has been proved to be partly involved with the improved action of vascular smooth muscle cells (VSMCs). This review focuses on the current knowledge of TRPV1 in improving VSMC function and attenuating hypertension.