Channelpedia

PubMed 25510104


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: Cav1.3



Title: [Influx of Ca2+ via Car1.3 calcium channels in satellite cells of muscle fibers in rats ].

Authors: V A Pochaev, A M Krasnyĭ, N D Ozerniuk

Journal, date & volume: Izv. Akad. Nauk. Ser. Biol., 2013 Sep-Oct , , 522-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/25510104


Abstract
Voltage-dependent L-type Cav1.3 channels have been detected in satellite cells localized to muscle fibers. It was established that the action of carbachol, which activates nicotinic acetylcholine receptors and causes cell membrane to depolarize, resulted in the activation of these channels. In addition, verapamil and amlodipine, selective L-type calcium channel blockers, suppressed extracellular calcium influx into the cytoplasm. It was noted that in a calcium-free medium, carbachol had no influence on the concentration of calcium in the cytoplasm of satellite cells, whereas adrenaline induced calcium efflux from intracellular stores. In addition, calcium influx into the cytoplasm was not suppressed by verapamil and amlodipine under the action of adrenaline and noradrenalin in a medium with calcium, and an ICI- 118551 blocker of β2-adrenoreceptros significantly decreased the increase in the concentration of calcium in the cytoplasm.