Channelpedia

PubMed 24070783


Referenced in Channelpedia wiki pages of: none

Automatically associated channels: KCNQ2 , Kv7.2



Title: Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.

Authors: Yong-Jin Wu, Charles M Conway, Li-Qiang Sun, Frederic Machet, Jie Chen, Ping Chen, Huan He, Clotilde Bourin, Vincenzo Calandra, Joseph L Polino, Carl D Davis, Karen Heman, Valentin K Gribkoff, Christopher G Boissard, Ronald J Knox, Mark W Thompson, William Fitzpatrick, David Weaver, David G Harden, Joanne Natale, Steven I Dworetzky, John E Starrett

Journal, date & volume: Bioorg. Med. Chem. Lett., 2013 Nov 15 , 23, 6188-91

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24070783


Abstract
Acrylamide (S)-6, a potent and efficacious KCNQ2 (Kv7.2) opener, demonstrated significant activity in two models of neuropathic pain and in the formalin test, suggesting that KCNQ2 openers may be useful in the treatment of neuropathic pain including diabetic neuropathy.