Referenced in: none

Automatically associated channels: TRP , TRPV , TRPV4

Title: Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion.

Authors: Liping Ning, Chuanwei Wang, Xiaohua Fan, Xinli Ding, Yonghui Wang, Yang Zhang, Jie Wang, Shouwei Yue

Journal, date & volume: Neurol. Res., 2014 Jan , 36, 70-8

PubMed link: http://www.ncbi.nlm.nih.gov/pubmed/24074178

Abstract
The aim of this study is to investigate the effect of microtubule depolymerization by colchicine on hyperalgesia mediated by transient receptor potential vanilloid 4 (TRPV4) in a neuropathic pain model of chronic compression of the dorsal root ganglion (DRG) (hereafter termed CCD) in rat. Intrathecal administration of microtubule-depolymerizing agent, colchicine, attenuated the activated effect of 4alpha-phorbol 12, 13-didecanoate (4alpha-PDD, TRPV4 specific agonist) on mechanical and thermal hyperalgesia in CCD rats. This observation is in agreement with our in vitro experiments with DRG cells that showed a significant attenuation of 4alpha-PDD-activated Ca(2+)-influx and substance P (SP) release with the colchicine treatment. We conclude that microtubule depolymerization by colchicine can regulate pain sensitivity by depressing the hyperalgesia mediated by TRPV4.